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EV-NHC
- Development stage
- Preclinical
- Lead developer
- Johns Hopkins University
- Modality
- Hydrogel Systems → Drug Delivery Systems, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intralesional
01
Overview
**EV-NHC** is an investigational, injectable extracellular-vesicle delivery formulation developed at Johns Hopkins University for **Crohn's disease perianal fistula**. It consists of mesenchymal stem cell-derived extracellular vesicles retained within a biodegradable nanofiber-hydrogel composite microgel matrix. The hydrogel carrier is designed to prolong local EV retention and enable sustained release at the fistula site, supporting anti-inflammatory and regenerative activity. In a rat model of Crohn's disease perianal fistula, EV-NHC reduced local inflammation and improved fistula healing, with findings consistent with macrophage polarization and enhanced neovascularization. It remains a preclinical research-stage therapeutic platform.
- Other names
- EV-loaded NHCEV-loaded nanofiber-hydrogel composite
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