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EV201
- Development stage
- Preclinical
- Lead developer
- Pfizer
- Modality
- Vaccines & Immunotherapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
EV201 is a preclinical therapeutic vaccine candidate developed by EV Therapeutics for the treatment of pancreatic ductal adenocarcinoma (PDAC). The therapy utilizes modified tumor-derived extracellular vesicles (mTEV) as a delivery platform for tumor-derived neoantigens. By leveraging the natural biocompatibility and signaling properties of extracellular vesicles, EV201 is designed to present these neoantigens to the immune system, thereby inducing a targeted anti-tumor T-cell response. It is being evaluated both as a standalone monotherapy and in combination with immune checkpoint inhibitors to enhance therapeutic efficacy in the immunosuppressive microenvironment of pancreatic cancer.
- Other names
- mTEV therapeutic vaccinemodified Tumor-derived Extracellular Vesicles
02
Targets
PVRL4 (Nectin cell adhesion molecule 4)
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