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EVE112
- Development stage
- Phase 4
- Lead developer
- Evestra
- Modality
- Small Molecules
- Administration
- Vaginal
01
Overview
**EVE112** is an investigational fixed-dose combined hormonal contraceptive drug-device product developed by Evestra. It is a polymeric vaginal ring that delivers the synthetic progestin **etonogestrel** and synthetic estrogen **ethinylestradiol** by the vaginal route. The hormonal combination suppresses hypothalamic-pituitary-ovarian signaling and inhibits ovulation, principally by preventing the gonadotropin surge; it also increases cervical-mucus viscosity and alters endometrial receptivity. EVE112 was evaluated in completed clinical studies in healthy women of childbearing potential, including an ovulation-inhibition study and a multicentre bleeding-pattern study for hormonal contraception. ([clinicaltrialsregister.eu](https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-000115-32/results))
- Other names
- EVE 112EVE112EVE-112
02
Targets
AR (Adrenergic receptors)ESR1 (ERα)ESR2 (ERβ)GR (Glucocorticoid receptor)PR (Progesterone receptor)
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