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evening primrose oil + misoprostol
- Development stage
- Unknown
- Lead developer
- Ain Shams University
- Modality
- Small Molecules
- Administration
- Vaginal
01
Overview
Evening primrose oil + misoprostol is an investigational combination therapy being studied by Ain Shams University for the management of second-trimester missed abortion. Evening primrose oil (EPO), derived from the *Oenothera biennis* plant, is rich in gamma-linolenic acid (GLA), which serves as a precursor to prostaglandin E1 (PGE1). When administered vaginally, EPO is thought to promote cervical ripening and effacement. Misoprostol is a synthetic prostaglandin E1 analog that induces uterine contractions and further aids in cervical softening. The combination is intended to shorten the induction-to-abortion interval in primiparous women, potentially reducing the time required for the complete expulsion of fetal and placental tissue.
- Brand names
- Primrose plusMisotac
- Other names
- EPOOenothera biennis oil
02
Targets
PTGER3 (Prostaglandin E2 receptor EP3 subtype)
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