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EVerGel
- Development stage
- Preclinical
- Lead developer
- EverZom
- Modality
- Hydrogel Systems → Drug Delivery Systems, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Topical, Rectal, Intralesional Injection
01
Overview
**EVerGel** is an investigational, locally delivered regenerative therapy developed for digestive-tissue healing. It consists of naïve exosomes derived from human adipose stem cells embedded in a thermoresponsive hydrogel; the liquid gel is injected at the injury site and undergoes in situ gelation at body temperature to improve local exosome retention and controlled release. Its lead indication is complex perianal fistula associated with Crohn's disease, with additional development interest in digestive anastomotic healing, stenosis, and postoperative adhesions. EVerGel has generated preclinical in vitro and in vivo proof-of-concept data and is intended for clinical development. ([everzom.com](https://everzom.com/therapeutic-programs/evergel/))
- Other names
- EVerGel
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