evernic acid

Evernic acid is a natural depside and secondary metabolite primarily isolated from lichen species such as *Evernia prunastri* (oakmoss). It is being extensively researched for its potential as an adjuvant in oncology, where it has demonstrated the ability to enhance the sensitivity of cancer cells to traditional chemotherapeutic agents like temozolomide and paclitaxel. Its mechanism of action involves the modulation of the Wnt signaling pathway and the exertion of immunomodulatory effects, which help overcome drug resistance in glioblastoma and breast cancer models. Additionally, evernic acid exhibits significant anti-inflammatory and antioxidant properties, leading to investigations into its neuroprotective potential, particularly in mitigating neuroinflammation and dopaminergic neuronal loss in models of Parkinson's disease.

Other names

2-hydroxy-4-[(2-hydroxy-4-methoxy-6-methylbenzoyl)oxy]-6-methylbenzoic acid