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evodia radix
- Development stage
- Unknown
- Lead developer
- The Fifth Medical Center of the PLA General Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Evodia radix, derived from the root of *Evodia rutaecarpa*, is a traditional Chinese medicinal substance being investigated by the Fifth Medical Center of PLA General Hospital for the treatment of chronic non-atrophic gastritis. The pharmacological activity is primarily attributed to quinolone alkaloids such as evodiamine and rutaecarpine. These compounds exhibit potent anti-inflammatory effects by inhibiting the NF-κB signaling pathway and reducing the production of pro-inflammatory cytokines like TNF-α and IL-6. Additionally, evodiamine acts as a transient receptor potential vanilloid 1 (TRPV1) agonist, which may play a role in modulating gastric mucosal blood flow and pain perception. In the context of chronic gastritis, Evodia radix is studied for its ability to protect the gastric mucosa, inhibit *Helicobacter pylori* growth, and alleviate symptoms associated with gastric inflammation.
- Other names
- Wu Zhu Yu GenRoot of Medicinal EvodiaEvodiae Radix
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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