evodiamine

**Evodiamine** is a naturally occurring indole alkaloid and the primary bioactive component of the fruit Evodia rutaecarpa (also known as Euodia rutaecarpa), a traditional Chinese medicinal plant. It exhibits a range of pharmacological activities, including **antitumor, anti-inflammatory, cardioprotective, anti-atherosclerotic, anti-nociceptive, anti-gastric ulcer, and neuroprotective** effects. As a small molecule inhibitor, evodiamine is noted for its ability to suppress proliferation and migration of vascular smooth muscle cells (VSMCs), attenuate inflammation and oxidative stress, and modulate hormone secretion. Its antitumor effects have been demonstrated in multiple mouse cancer models, including colon, liver, lung, cervical, ovarian, pancreatic, breast, and lymphoma, with significant inhibition of tumor growth. The mechanism of action includes multi-target activity, with documented inhibition of the **PI3K/Akt signaling axis**, leading to reduced proliferation, migration, and inflammatory responses in vascular cells and cancer cells[1][3][4].

Other names

evodiamineisoevodiaminevodiaminecornishined-evodiaminedogwood baseevodiamine 98%evodiamine.p.eevodiamine std.