Exalgo (Mallinckrodt Pharmaceuticals)

Exalgo is an extended-release, once-daily oral formulation of hydromorphone hydrochloride, a semi-synthetic opioid analgesic. It utilizes the OROS (Osmotic Release Oral System) delivery technology, which employs osmotic pressure to deliver the drug at a controlled rate through a laser-drilled orifice. This mechanism ensures stable plasma concentrations over a 24-hour period, reducing the "peak-and-trough" effect common with immediate-release formulations. Developed by Mallinckrodt, Exalgo is indicated for the management of moderate to severe pain in opioid-tolerant patients requiring continuous, around-the-clock opioid therapy. Clinical studies have specifically evaluated its efficacy and safety in patients with chronic osteoarthritis pain of the hip or knee.

Brand names

Exalgo

Other names

OROS hydromorphonehydromorphone hydrochloride extended-release