exemestane

Exemestane is an oral, steroidal aromatase inhibitor used primarily to treat hormone-sensitive breast cancer in postmenopausal women. It works by irreversibly binding to and inactivating the aromatase enzyme, which is responsible for converting androgens into estrogens in peripheral tissues. By blocking this conversion, exemestane significantly lowers estrogen levels, thereby slowing or stopping the growth of estrogen-dependent breast tumors. Exemestane is indicated for early and advanced breast cancer in postmenopausal women who have previously been treated with tamoxifen or whose disease has progressed during such therapy. The drug was developed as a "suicide inhibitor," meaning it permanently deactivates its target enzyme through irreversible binding.

Brand names

Aromasin

Other names

exemestane