Drug intelligence / Profile preview

exemestane + ribociclib

Development stage: Unknown
Lead developer: Novartis
Modality: Small Molecules
Administration: Oral

Overview

Exemestane + ribociclib is a combination therapy used to treat hormone receptor-positive (HR+), HER2-negative breast cancer. Exemestane is an aromatase inhibitor that decreases estrogen production, while ribociclib is a CDK4/6 inhibitor that blocks cell cycle progression. This combination targets both hormonal and cell cycle regulatory pathways to inhibit cancer cell growth and proliferation.

Targets

CDK6 (Cyclin-dependent kinase 6)CDK4 (Cyclin-dependent kinase 4)CYP19A1 (Aromatase)

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