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exendin-asp3
- Development stage
- Preclinical
- Modality
- Peptides
- Administration
- Subcutaneous, Intravenous
01
Overview
Exendin-asp3 (ExD3) is a modified peptide agonist of the glucagon-like peptide-1 receptor (GLP-1R), derived from the structure of exendin-4. It is characterized as a biased agonist that specifically promotes rapid internalization of the GLP-1R into endosomes. Despite its high propensity for driving receptor trafficking and its accumulation in endocytic compartments, research indicates that exendin-asp3 is a relatively inefficient driver of cAMP production in pancreatic β-cells and insulin secretion from the pancreas compared to other GLP-1R agonists. It is primarily utilized as a pharmacological tool in research to investigate the spatial distribution of GPCR signaling and the therapeutic implications of biased agonism in the treatment of type 2 diabetes and obesity.
- Other names
- ExD3ExD-3ExD 3Asp3-exendin-4Asp-3-exendin-4Asp 3-exendin-4
02
Targets
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