exosomes derived from human induced pluripotent stem cell

Exosomes derived from human induced pluripotent stem cells (hiPSCs) are nanoscale extracellular vesicles secreted by hiPSCs or their differentiated progeny. These exosomes act as paracrine mediators and deliver bioactive molecules such as proteins, lipids, and microRNAs to recipient cells. They have demonstrated therapeutic effects in preclinical models of cardiovascular disease (e.g., myocardial infarction), skin aging and regeneration, limb ischemia, corneal epithelial defects, neural injury (including neuroprotection after oxygen-glucose deprivation), and other tissue injuries. Mechanistically, these exosomes promote angiogenesis, inhibit apoptosis and fibrosis, stimulate cell proliferation and migration (notably in dermal fibroblasts and endothelial cells), modulate inflammation via miRNA cargoes like miR-126 or regulatory proteins such as Jagged-1/Notch pathway components or VEGFR2 signaling. Unlike the parent hiPSCs—which carry a risk of tumorigenicity—exosome-based therapies offer a safer cell-free alternative for regenerative medicine applications[1][2][3][4][5][6][8].

Other names

hiPSC-exosomesiPSC-ExosiPSCs-Exoexosomes from human induced pluripotent stem cells