Drug intelligence / Profile preview

ExPEC9

Development stage
Preclinical
Lead developer
Johnson & Johnson
Modality
Vaccines & Immunotherapeutics
Administration
Parenteral
01

Overview

ExPEC9 is a 9-valent conjugate vaccine candidate developed by Shandong Kunli Biopharmaceutical, targeting extraintestinal pathogenic Escherichia coli (ExPEC). The vaccine is designed to prevent a range of serious conditions caused by ExPEC, including urinary tract infections (UTI), sepsis, and neonatal meningitis, by inducing an immune response against nine specific E. coli serotypes. As a conjugate vaccine, it likely consists of bacterial polysaccharides chemically linked to a carrier protein to enhance its immunogenicity, particularly in vulnerable populations. It is currently in the preclinical stage of development.

Other names
9价肠外致病性大肠埃希菌疫苗9-valent extraintestinal pathogenic E. coli vaccine
02

Targets

Extraintestinal pathogenic Escherichia coli O-antigen polysaccharide serotype O15Escherichia coli O16 O-antigen polysaccharideO18A (Escherichia coli O18A O-antigen polysaccharide)Extraintestinal pathogenic Escherichia coli O-antigen polysaccharide serotype O1AO2 antigen (Escherichia coli O2 antigen)O25b (Escherichia coli O25b antigen)Escherichia coli O4 O-antigen polysaccharideExtraintestinal pathogenic Escherichia coli O6A O-antigen polysaccharideO75 (Escherichia coli O75 O-antigen polysaccharide)EDNRA (Endothelin receptor type A)

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