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ExPEC9
- Development stage
- Preclinical
- Lead developer
- Janssen Pharmaceutical
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Parenteral
01
Overview
ExPEC9 is a 9-valent conjugate vaccine candidate developed by Shandong Kunli Biopharmaceutical, targeting extraintestinal pathogenic Escherichia coli (ExPEC). The vaccine is designed to prevent a range of serious conditions caused by ExPEC, including urinary tract infections (UTI), sepsis, and neonatal meningitis, by inducing an immune response against nine specific E. coli serotypes. As a conjugate vaccine, it likely consists of bacterial polysaccharides chemically linked to a carrier protein to enhance its immunogenicity, particularly in vulnerable populations. It is currently in the preclinical stage of development.
- Other names
- 9价肠外致病性大肠埃希菌疫苗9-valent extraintestinal pathogenic E. coli vaccine
02
Targets
Escherichia coli O4 O-antigen polysaccharideO25b (Escherichia coli O25b antigen)EDNRA (Endothelin receptor type A)O18A (Escherichia coli O18A O-antigen polysaccharide)Extraintestinal pathogenic Escherichia coli O-antigen polysaccharide serotype O15Escherichia coli O16 O-antigen polysaccharideO2 antigen (Escherichia coli O2 antigen)Extraintestinal pathogenic Escherichia coli O-antigen polysaccharide serotype O1AExtraintestinal pathogenic Escherichia coli O6A O-antigen polysaccharideO75 (Escherichia coli O75 O-antigen polysaccharide)
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