Drug intelligence / Profile preview

extract of fresh opium poppy

Development stage
Unknown
Lead developer
Region Östergötland
Modality
Small Molecules
Administration
Oral
01

Overview

Extract of fresh opium poppy is an investigational herbal preparation derived from the *Papaver somniferum* plant. Developed by researchers at Region Östergötland in Sweden, it is being evaluated for its potential to alleviate symptoms associated with ureteral stents and other urological conditions such as nephrolithiasis and vesicoureteral reflux. The extract contains a complex mixture of opium alkaloids, including morphine, codeine, thebaine, papaverine, and noscapine. These components act primarily as agonists at opioid receptors (mu, kappa, and delta) and as smooth muscle relaxants (via phosphodiesterase inhibition by papaverine). The primary goal of its use in urology is to reduce ureteral spasms and pain following surgical procedures like ureteroscopy or stent placement for renal and ureteral cancers or stones.

Other names
Papaver somniferum extractFresh opium poppy extractVallmoextrakt
02

Targets

MOR (Mu opioid receptor)KOR (Kappa opioid receptor)DOR (Opioid Receptor Delta 1)PDE (Phosphodiesterase family)

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