Drug intelligence / Profile preview

extract of green tea + extract of black tea

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing extracts from both green tea and black tea leaves, both derived from the plant Camellia sinensis. Green tea extract is rich in catechins—especially epigallocatechin gallate (EGCG)—while black tea extract contains theaflavins and thearubigins as its primary bioactive compounds. Both types of extracts are sources of caffeine, polyphenols, and other methylxanthines such as theobromine and theophylline. The main mechanisms attributed to these extracts include antioxidant activity via neutralization of free radicals, mild stimulation due to caffeine content, potential enzymatic inhibition affecting cholesterol metabolism (notably by EGCG on HMG-CoA reductase), uric acid metabolism (via xanthine oxidase inhibition), glucose transport modulation, and possible diuretic effects. While some studies suggest benefits for cardiovascular health, metabolic syndrome risk reduction, cancer prevention or progression delay, weight management support, alertness enhancement due to caffeine content, and cholesterol lowering effects—clinical evidence remains mixed or inconclusive for most indications[2][5][6][8]. Excessive intake may cause side effects such as liver toxicity (especially with high-dose green tea extracts), gastrointestinal upset, insomnia or anxiety due to caffeine content[1][7]. This combination is marketed primarily as a dietary supplement rather than a pharmaceutical drug.

Other names
green tea extract + black tea extractCamellia sinensis leaf extracts (green and black)polyphenol blend (green and black tea)
02

Targets

ADORA1 (Adenosine receptor A1 subtype)BCL2L1 (B-cell lymphoma-extra large protein)COMT (Catechol-O-methyltransferase)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)OAT1 (Organic anion transporter 1)Phospholipid vesicle and cellular membraneXO (Xanthine Oxidoreductase)ADOR (Adenosine receptors)GLUT (Glucose transporter family)

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