Drug intelligence / Profile preview

Ezerrosu

Development stage
Unknown
Lead developer
Shinpoong Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Ezerrosu (also spelled Ezerosu) is a fixed-dose combination (FDC) small molecule therapy developed by Shin Poong Pharmaceutical for the treatment of hyperlipidemia. It consists of two active ingredients: ezetimibe and rosuvastatin. Ezetimibe acts by inhibiting the Niemann-Pick C1-like 1 (NPC1L1) protein in the small intestine, thereby reducing the absorption of dietary and biliary cholesterol. Rosuvastatin is a statin that competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in hepatic cholesterol synthesis. The combination provides a synergistic effect in lowering low-density lipoprotein cholesterol (LDL-C) and is approved for use in South Korea.

Brand names
EzerrosuEzerosu
Other names
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02

Targets

NPC1L1 (Niemann-pick C1-Like 1 transporter)

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