Drug intelligence / Profile preview

ezetimibe + ursodeoxycholic acid + voglibose

Development stage
Preclinical
Lead developer
Merck
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination therapy consisting of ezetimibe, ursodeoxycholic acid (UDCA), and voglibose. Ezetimibe is a cholesterol absorption inhibitor that lowers total cholesterol, LDL-C, Apo-B, and non-HDL-C in primary hyperlipidemia. Ursodeoxycholic acid is a secondary bile acid primarily produced by intestinal microbiota that has shown beneficial effects against non-alcoholic fatty liver disease (NAFLD). Voglibose is an alpha-glucosidase inhibitor used to treat type 2 diabetes mellitus by inhibiting intestinal enzymes responsible for breaking complex sugars into simple sugars, thereby preventing blood glucose levels from rising immediately after meals.

02

Targets

ABCB11 (Bile salt export pump)FXR (Farnesoid x-activated receptor)NPC1L1 (Niemann-pick C1-Like 1 transporter)OATP (Organic anion transporting polypeptides)NTCP (Na+-taurocholate cotransporting polypeptide)Sucrase-Isomaltase

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