F-18 3F4AP

**F-18 3F4AP** is a radiolabeled small molecule positron emission tomography (PET) tracer developed for imaging demyelination in the central nervous system. It is a fluorinated analog of the FDA-approved multiple sclerosis drug 4-aminopyridine (fampridine), specifically labeled with fluorine‑18 for PET imaging. The compound binds to exposed voltage-gated potassium channels that become accessible when myelin sheaths are lost due to demyelinating diseases such as multiple sclerosis (MS), Alzheimer's disease, and traumatic brain injury. By targeting these potassium channels, F‑18 3F4AP enables visualization and quantification of demyelinated lesions in vivo. The tracer has demonstrated metabolic stability and high specificity for demyelinated regions in preclinical models and early human studies[1][6][8]. Its primary use is investigational as a diagnostic tool to assess myelin integrity in neurological disorders.

Other names

F18-3F4APF-18-3F4APF 18-3F4AP[^18F]3-fluoro-4-aminopyridine