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F12-MMAE
- Development stage
- Preclinical
- Modality
- Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
F12-MMAE is a preclinical **antibody-drug conjugate** composed of the fully human anti-prostate stem cell antigen antibody F12, formatted as an IgG1, conjugated to the tubulin inhibitor monomethyl auristatin E. It was described in academic research as a highly specific PSCA-targeting ADC for prostate cancer, with the F12 antibody reported to bind PSCA amino acids 63-69, internalize efficiently into PSCA-expressing tumor cells, and cross-react with murine PSCA. In a human PC-3-PSCA xenograft NSG mouse model, F12-MMAE showed dose-dependent and antigen-specific antitumor activity, supporting its development as a targeted antineoplastic candidate for prostate cancer and potentially other PSCA-expressing solid tumors.
- Other names
- IgG1 F12-MMAEIgG-1 F12-MMAEIgG 1 F12-MMAEF12 ADCF-12 ADCF 12 ADC
02
Targets
PSCA (Prostate stem cell antigen)TUBB (Tubulin (alpha and beta subunits))
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