Drug intelligence / Profile preview

F44-A13

Development stage
Unknown
Lead developer
Peking University
01

Overview

F44-A13: sourced facts only. name: "These findings highlight that F44-A13 is a highly selective FXR antagonist that might serve as a useful molecule for further FXR studies as well as the development of FXR antagonists for the potential treatment of metabolic diseases with lipid disorders." [PMID:38547735]; target: "These findings highlight that F44-A13 is a highly selective FXR antagonist that might serve as a useful molecule for further FXR studies as well as the development of FXR antagonists for the potential treatment of metabolic diseases with lipid disorders." [PMID:38547735]; developer: "State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China." [PMID:38547735]; stage: "Pharmacological studies conducted on C57BL/6 mice further confirmed that compound F44-A13 had beneficial effects in reducing cholesterol, triglycerides, and LDL-C levels." [PMID:38547735]

02

Targets

FXR (Farnesoid x-activated receptor)

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