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F5 TCR transgenic cells + MART-1 peptide pulsed dendritic cells
- Development stage
- Unknown
- Lead developer
- University of California, Los Angeles
- Modality
- TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies
- Administration
- Intradermal, Intravenous
01
Overview
A combination cancer immunotherapy approach consisting of T cells genetically engineered to express the F5 T cell receptor (which recognizes MART-1 antigen) and autologous dendritic cells pulsed with MART-1 peptide. The MART-1 peptide-pulsed dendritic cells serve as antigen-presenting cells that can activate and enhance the anti-tumor activity of the F5 TCR transgenic T cells. This approach is designed to generate potent immune responses against melanoma cells expressing the MART-1/Melan-A antigen, which is present in over 90% of melanomas.
02
Targets
MART-1/HLA-A*02:01 (Melanoma-associated antigen (Melanoma antigen recognized by T cells 1, Melanocyte protein PMEL, Tyrosinase) peptide-HLA-A*02:01 complex)
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