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FA-DOX-Ng
- Development stage
- Preclinical
- Modality
- Nanoparticles → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
**FA-DOX-Ng** is an experimental folate receptor-targeted, doxorubicin-loaded chitosan nanogel developed as a pH-responsive nanomedicine for colorectal cancer. Folic-acid surface targeting is intended to enhance folate receptor-mediated uptake by tumor cells, while the chitosan nanogel carrier releases doxorubicin preferentially in acidic tumor-associated conditions. In HT-29 colorectal cancer cells, the formulation increased doxorubicin cytotoxicity and induced apoptosis, with reported modulation of PTEN, AKT, BAX, BCL2, and caspase-associated apoptotic signaling. It is a preclinical delivery formulation rather than an approved pharmaceutical product.
- Other names
- folate-conjugated doxorubicin-loaded chitosan nanogel
02
Targets
DNAFOLR1 (FRα)TOP2A (DNA topoisomerase II)
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