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FA-FE-SBA15QN

Development stage: Preclinical
Lead developer: CSIR-Indian Institute of Chemical Biology
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Parenteral

Overview

**FA-FE-SBA15QN** is an experimental, folic-acid-functionalized, magnetite-embedded SBA-15 mesoporous silica nanoparticle formulation loaded with the flavonoid **quercetin**. It was designed as a pH-sensitive, folate-directed nanocarrier for colorectal cancer, with magnetite providing magnetic-resonance-imaging contrast potential. In HCT-116 colorectal carcinoma cells and CT-26 tumor-bearing mice, the formulation produced tumor-suppressive effects associated with reactive-oxygen-species generation, mitochondrial apoptosis, JNK-mediated H2AX phosphorylation, p53 signaling, and inhibition of heat shock protein 27. It is a preclinical theranostic nanomedicine and is not an approved medicinal product. ([pubs.rsc.org](https://pubs.rsc.org/az/content/articlehtml/2020/ra/d0ra00664e))

Other names: FA-FE-SBA-15-QNFA-FE-SBA15-QNFA-FE-SBA 15-QNFA-FE-SBA15QNFA-FE-SBA-15QNFA-FE-SBA 15QNFA-IO-SBA-15-QNFA-IO-SBA15-QNFA-IO-SBA 15-QN

Targets

FOLR1 (FRα)BAX (Apoptosis regulator BAX)PCNA (Proliferating cell nuclear antigen)JNK (Mitogen-activated protein kinase kinase kinase family)HSPB1 (Heat shock protein beta-1)TP53 (Cellular Tumor Antigen p53 R175H)

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