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FA-GC-PBA
- Development stage
- Preclinical
- Lead developer
- Jinan University
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
FA-GC-PBA is a targeted, reactive oxygen species (ROS)-responsive nanotherapeutic platform developed for the treatment of cancers overexpressing the folate receptor, such as cervical cancer. The system consists of a glycol chitosan (GC) backbone functionalized with folic acid (FA) for active tumor targeting and phenylboronic acid (PBA) for ROS-triggered payload release. In preclinical research, this polymer is used to encapsulate selenium nanoparticles (SeNPs) to form FA-ReRSeNPs. This precision-driven nanotherapeutic enhances the delivery of selenium to tumor sites while minimizing off-target toxicity. Mechanistically, the released selenium inhibits the PI3K/AKT signaling pathway, which induces apoptosis and suppresses the proliferation of human cervical cancer cells (e.g., HeLa and SiHa).
- Other names
- Folic acid-conjugated glycol chitosan-phenylboronic acidFA-GC-PBA-SeNPsFolic acid-targeted ROS-responsive selenium nanoparticles
02
Targets
FOLR1 (FRα)AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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