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faecal microbiota transplantation
- Development stage
- Preclinical
- Lead developer
- Aarhus University
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Rectal
01
Overview
Faecal microbiota transplantation (FMT) is an investigational live biotherapeutic product involving the transfer of fecal microorganisms from a healthy donor to a recipient. [5, 9] The aim is to restore a healthy gut microbiome, which is often disturbed (dysbiosis) in various diseases. [5, 7] This specific intervention, studied by Aarhus University, targets patients with liver cirrhosis to prevent complications, slow disease progression, and reduce mortality. [3, 9] The underlying principle is that correcting dysbiosis will improve gut barrier function, reduce systemic inflammation, and modulate the gut-liver axis. [2, 4, 5]
- Other names
- FMTfaecal microbial transplantfecal microbiota transplantation
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