falecalcitriol

Falecalcitriol is a **fluorinated derivative of vitamin D3** that acts as a regulator of calcium metabolism, primarily by stimulating absorption of calcium from the gut and regulating bone mineralization. It belongs to the dihydroxycholecalciferols class and is specifically known as hexafluorocalcitriol due to six fluorine substitutions. Its mechanism of action closely resembles calcitriol, functioning as an agonist at the vitamin D receptor, thereby promoting calcium absorption, modulating bone formation, and regulating parathyroid hormone levels. It is used for conditions such as hyperparathyroidism, osteomalacia, and rickets[9][6].

Brand names

FlocalcitriolFulstanHexafluorocalcitriolHexafluorovitamin D3Hornel

Other names

falecalcitriol(+)-(5Z,7E)-26,26,26,27,27,27-hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1alpha,3beta,25-triol