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falimarev
- Development stage
- Phase 2
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Falimarev is a therapeutic cancer vaccine composed of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), mucin 1 (MUC1), and TRICOM, which consists of three co-stimulatory molecule transgenes (B7‑1, ICAM‑1, and LFA‑3). The vaccine is designed to enhance the presentation of CEA and MUC1 antigens to antigen-presenting cells, thereby stimulating a cytotoxic T-cell response against tumor cells expressing these antigens. Falimarev has been investigated primarily for use in various cancers including colorectal cancer, metastatic cancer, pancreatic adenocarcinoma, and other solid tumors[2][4][5].
- Brand names
- PANVAC-F
- Other names
- falimarev
02
Targets
CEACAM5 (Carcinoembryonic antigen related cell adhesion molecule 5)CD80 (T-lymphocyte activation antigen CD80)CD58 (Leukocyte function-associated antigen 3)ICAM1 (Intercellular Adhesion Molecule 1)MUC1 (Mucin-1 Antigen)
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