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Falkieri
- Development stage
- Unknown
- Lead developer
- Celon Pharma
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
Falkieri is an investigational esketamine-based therapeutic being developed by Celon Pharma SA, specifically formulated for dry powder inhalation (DPI). As a small molecule NMDA receptor antagonist, it targets the glutamatergic system to provide rapid antidepressant effects. Unlike intranasal liquid formulations, Falkieri is delivered via a dry powder inhaler, which is designed to enhance drug delivery efficiency to the lungs and improve dosing precision. The drug has primarily been evaluated as an adjunctive treatment for treatment-resistant bipolar depression (TRBD), where Phase II clinical trials demonstrated statistically significant reductions in depressive symptoms on the MADRS scale compared to placebo. Notably, clinical data suggests the drug is well-tolerated with a favorable safety profile, including a lack of manic switching, which is a critical concern in the treatment of bipolar disorders.
- Brand names
- Falkieri
- Other names
- inhaled esketamineEsketamine CelonCelon esketamine
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)
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