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famciclovir + gabapentin
- Development stage
- Unknown
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of the antiviral agent famciclovir and the anticonvulsant gabapentin, utilized in the management of acute herpes zoster (shingles) and the prevention or treatment of postherpetic neuralgia (PHN). Famciclovir is a prodrug of penciclovir that inhibits viral DNA polymerase, thereby suppressing viral replication. Gabapentin acts by binding to the alpha-2/delta-1 subunit of voltage-gated calcium channels in the central nervous system, modulating the release of excitatory neurotransmitters to alleviate neuropathic pain. This specific combination is being studied by investigator Xiaguang Duan in clinical trials evaluating the additive efficacy of multimodal nerve blocks and pulsed radiofrequency for severe zoster-associated pain.
- Other names
- famciclovir and gabapentin
02
Targets
DNA polymerase familyCACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (α2δ-2)
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