Drug intelligence / Profile preview

Fangxiang Wentong

Development stage: Unknown
Lead developer: China Academy of Chinese Medical Sciences
Modality: Small Molecules
Administration: Inhalation, Sublingual

Overview

Fangxiang Wentong is a Traditional Chinese Medicine (TCM) prescription, with Kuanxiong Aerosol being a specific formulation. It is a compound preparation consisting of five traditional Chinese medicines: Herba Asari, Rhizoma Alpiniae Officinarum, Lignum Santali Albi, Fructus Piperis Longi, and Borneolum. It has been traditionally used for conditions like angina pectoris and is currently under investigation for coronary microvascular disease (CMVD). Its therapeutic effects are attributed to multiple mechanisms including anti-myocardial ischemia, anti-inflammation, anti-oxidation, improvement of endothelial function, and immune modulation via the NOTCH1 pathway. It also influences various biomarkers such as Endothelin-1, C-reactive protein, and Nitric Oxide.

Other names: Kuanxiong AerosolKuanxiong (KX) AerosolAromatic WentongKXAKA

Targets

RELA (Nuclear Factor Kappa B Subunit p65)IL-6 (Interleukin 6)

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