FAP-alpha small interfering RNA-1

FAP-alpha small interfering RNA-1 is an experimental RNA interference (RNAi) therapeutic agent designed to silence the expression of Fibroblast Activation Protein alpha (FAP-α). FAP-α is a pro-tumorigenic serine protease overexpressed in the stroma of various cancers, including prostate cancer, where it promotes tumor cell proliferation, invasion, and survival. This specific siRNA sequence targets FAP-α mRNA for degradation, thereby reducing protein expression. Preclinical studies in prostate cancer models (DU145 and LNCaP cells) have demonstrated that knockdown of FAP-α using this siRNA inhibits the nuclear translocation of β-catenin, suppresses tumor cell invasion and proliferation, and induces apoptosis. In vivo experiments in nude mice have shown significant reductions in tumor volume and weight following treatment with this agent.

Other names

FAP-alpha-siRNA-1FAP-alpha-siRNA1FAP-alpha-siRNA 1siRNA targeting FAP-α