Drug intelligence / Profile preview

Fasiject Plus

Development stage
Unknown
Lead developer
Agrovet Market
Modality
Small Molecules
Administration
Intramuscular, Subcutaneous
01

Overview

**Fasiject Plus** is a veterinary antiparasitic combination injectable developed by Agrovet Market that contains **triclabendazole** and **ivermectin**, two small-molecule endectocidal agents used for broad parasite control in livestock. The product is formulated as an injectable solution containing triclabendazole 360 mg/mL and ivermectin 6 mg/mL, and is administered by intramuscular or subcutaneous injection at 1 mL per 30 kg body weight. Its intended use is the treatment and control of mixed parasitic infestations in animals such as cattle, sheep, goats, and camelids, with activity against **Fasciola hepatica** including adult and immature liver flukes, gastrointestinal nematodes, and certain ectoparasites including mites, lice, and fly larvae. Mechanistically, triclabendazole is a benzimidazole flukicide that disrupts parasite microtubule-dependent processes through binding to parasite tubulin, while ivermectin is a macrocyclic lactone that activates glutamate-gated chloride channels in invertebrates, producing parasite neuromuscular paralysis and death.

Brand names
Fasiject Plus
Other names
triclabendazole + ivermectin
02

Targets

GluCl (Glutamate-gated chloride channel)TUBB (Tubulin (alpha and beta subunits))

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