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Drug intelligence / Profile preview
fasudil hydrochloride + PD1 inhibitor
- Development stage
- Preclinical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Fasudil hydrochloride + PD1 inhibitor is a combination therapy that pairs a Rho-kinase (ROCK) inhibitor with an immune checkpoint inhibitor. Fasudil hydrochloride is a potent and selective ROCK1/2 inhibitor that has been used in Japan since the 1990s for treating cerebral vasospasm following subarachnoid hemorrhage. PD1 inhibitors are a class of checkpoint inhibitor anticancer drugs that block the activity of PD-1 immune checkpoint proteins, preventing cancer cells from evading immune detection. This combination is being investigated for potential synergistic effects in cancer treatment, particularly in prostate cancer.
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)ROCK1 (Rho-associated coiled-coil containing protein kinase 1)ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
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