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fat-soluble vitamins

Development stage: Phase 3
Lead developer: First Affiliated Hospital of Xi'an Jiaotong University
Modality: Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration: Intravenous

Overview

Fat-soluble vitamins is a combination pharmaceutical product containing vitamins A, D, E, and K, formulated for intravenous administration. This specific intervention is being evaluated by the First Affiliated Hospital of Xi'an Jiaotong University in a Phase 3 clinical trial (NCT04121442) to address deficiencies in very low birth weight (VLBW) infants. The treatment aims to prevent or mitigate common neonatal complications, including bronchopulmonary dysplasia, sepsis, patent ductus arteriosus, and anemia, while supporting neural development. Vitamin A (retinol) is essential for vision and immune function; Vitamin D (cholecalciferol/ergocalciferol) regulates bone metabolism and calcium homeostasis; Vitamin E (alpha-tocopherol) provides antioxidant protection against oxidative stress; and Vitamin K (phytomenadione) is a critical cofactor for blood coagulation.

Other names: Vitamin A + Vitamin D + Vitamin E + Vitamin KFat-soluble Vitamins Injection (II)Vitalipid

Targets

PPARD (Peroxisome proliferator–activated receptor delta)RARA (Retinoic acid receptor alpha)VDR (Vitamin D receptor)GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)

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