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Drug intelligence / Profile preview
fazpilodemab
- Development stage
- Phase 1
- Lead developer
- Genentech
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
Fazpilodemab is a humanized, agonistic bispecific monoclonal antibody that targets fibroblast growth factor receptor 1c (FGFR1c) and Klotho beta (KLB). It was developed for the treatment of non-alcoholic steatohepatitis (NASH), with additional investigation in type 2 diabetes mellitus and non-alcoholic fatty liver disease. Fazpilodemab acts as an agonist at FGFR1c/KLB complexes, aiming to reduce liver fat and improve metabolic parameters. The drug was developed by Genentech, a subsidiary of Roche. Clinical development reached phase II for NASH but was terminated due to strategic business reasons[1][3][4][5].
- Other names
- anti-FGFR1/KLB bispecific antibodyFGF21 mimetic antibodyFGF-21 mimetic antibodyFGF 21 mimetic antibody
02
Targets
FGFR-KLB complex (Fibroblast growth factor receptor 1c / beta-Klotho complex)FGFR1 (Fibroblast growth factor receptor 1)KLB (Beta-Klotho)
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