Drug intelligence / Profile preview

Fe(III)-tannic acid

Development stage
Preclinical
Lead developer
Nanjing Drum-Tower Hospital
Modality
Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

**Fe(III)-tannic acid** is an iron(III)-polyphenol coordination material investigated as the redox-active core of ultrasmall dopamine-modified hyaluronic acid-stabilized nanoparticles for atherosclerosis. In the reported preclinical formulation, the nanoparticles preferentially accumulated in inflammatory plaque macrophages, enhanced magnetic-resonance imaging contrast, and used acidic, hydrogen peroxide-rich intracellular conditions to generate reactive oxygen species and induce inflammatory-macrophage death. The work is an early preclinical nanomedicine study rather than a marketed or clinically established therapy. ([europepmc.org](https://europepmc.org/article/MED/34279905))

Other names
Fe(III)-tannic acidFe(III)-tannic acid complexiron(III)-tannic acid complex
02

Targets

CD44 (CD44 antigen)

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