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fecal filtrate transplant

Development stage: Unknown
Lead developer: Vrije University Medical Center
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Fecal filtrate transplant (FFT) is an investigational microbiome-based biological therapy developed by the Academisch Medisch Centrum (Amsterdam University Medical Centers). It consists of a sterile, bacteria-free filtrate derived from the stool of lean, healthy donors, which is highly enriched with bacteriophages—viruses that infect and modulate specific bacterial populations. By transferring the donor's "virome" without the bacterial cells, FFT aims to reshape the recipient's gut microbiota to improve glucose metabolism and insulin sensitivity. It has been primarily studied in clinical trials for the treatment of metabolic syndrome and insulin resistance, representing a refined alternative to traditional fecal microbiota transplantation (FMT) that focuses on the therapeutic potential of the phageome.

Other names: faecal filtrate transplantationFFTbacteriophage-enriched fecal filtrate

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