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fecal filtrate transplantation
- Development stage
- Unknown
- Lead developer
- University of Pécs
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Fecal filtrate transplantation (FFT) is an investigational biologic therapy being developed by the University of Pécs for the treatment of recurrent Clostridioides difficile infection (rCDI). Unlike conventional fecal microbiota transplantation (FMT), FFT utilizes a sterile filtrate of donor stool, which has had all intact microorganisms removed. The active components consist of non-living bacterial products, including metabolites, bacteriophages, proteins, antimicrobial compounds, and bacterial DNA. The proposed mechanism is the restoration of gut homeostasis without transferring live bacteria, which could offer a significant safety advantage for immunocompromised patients by eliminating the risk of pathogenic transmission. The University of Pécs is conducting the FILTRATE trial, a Phase 3 study comparing lyophilized fecal filtrate capsules to conventional FMT for treating multiple recurrent CDI. [2]
- Other names
- FFTSterile stool filtratelyophilized fecal filtrate transplantation
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