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Fecal Inoculum Capsule

Development stage: Unknown
Lead developer: Massachusetts General Hospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Fecal Inoculum Capsule is an oral fecal microbiota transplant (FMT) product developed by Massachusetts General Hospital for the treatment of gut dysbiosis in individuals with HIV infection. The therapy consists of sieved fecal matter from healthy donors, prepared in a glycerol/saline solution and encapsulated for oral administration. In the context of HIV, chronic inflammation and immune activation often persist despite effective antiretroviral therapy (ART), a condition frequently linked to alterations in the gut microbiome and impaired intestinal barrier function (leaky gut). This FMT product aims to restore a diverse and healthy microbial community, thereby potentially reducing systemic inflammation and improving the immunological profile of HIV-infected patients.

Other names: Fecal Microbiota TransplantFMTFecal Inoculum

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