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fecal microbiota
- Development stage
- Unknown
- Lead developer
- Academy of Military Medical Sciences
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Cell Therapies
- Administration
- Rectal, Oral
01
Overview
Fecal microbiota transplantation (FMT) is a therapeutic procedure where fecal matter from a healthy donor is transferred into the gastrointestinal tract of a recipient. This specific intervention, developed by the Affiliated Hospital to Academy of Military Medical Sciences, is being evaluated for the treatment of steroid-resistant acute graft-versus-host disease (aGVHD) of the gut. The therapy aims to restore intestinal microbial diversity, which is typically depleted in aGVHD patients, thereby modulating the mucosal immune system and reducing intestinal inflammation. By re-establishing a healthy microbial community, FMT may help suppress the inflammatory processes that drive gut-associated GVHD.
- Other names
- Fecal Microbiota TransplantationFMTstool transplant
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