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Fecal Microbiota Transfer

Development stage: Unknown
Lead developer: Medical University of Warsaw
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal

Overview

Fecal Microbiota Transfer (FMT) is an investigational microbial therapy being developed and evaluated by the Medical University of Warsaw, in collaboration with the Human Biome Institute, for the treatment of Parkinson's disease. The therapy, specifically studied in the EFFACE-PD trial, involves the administration of healthy donor microbiota into the patient's intestine via colonoscopy. The primary objective is to modulate the gut-brain axis and restore a healthy intestinal microbiome, which is often dysbiotic in Parkinson's patients. By correcting this dysbiosis, the treatment aims to slow the progression of motor symptoms, alleviate chronic constipation, and potentially improve the absorption and pharmacokinetics of levodopa. This approach targets the systemic and neuroinflammatory pathways linked to gut health in neurodegenerative disorders.

Other names: FMTFecal Microbiota Transplantation

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