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fecal microbiota transplant (Faculty Hospital Kralovske Vinohrady)
- Development stage
- Unknown
- Lead developer
- Faculty Hospital Kralovske Vinohrady
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Cell Therapies, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal, Nasogastric
01
Overview
Fecal microbiota transplant (FMT) is a biological therapy consisting of the transfer of distal gut microbial communities from a healthy donor to a patient with intestinal dysbiosis. Developed as a clinical protocol by Fakultni Nemocnice Kralovske Vinohrady (University Hospital Kralovske Vinohrady), this specific allogeneic transplant is primarily investigated for the treatment of post-antibiotic diarrhea and *Clostridioides difficile* infection. The therapy works by re-establishing a diverse and functional microbiome, which provides colonization resistance against pathogens, restores normal bile acid metabolism, and helps resolve gut inflammation. It is typically administered via colonoscopy, enema, or oral capsules containing frozen or lyophilized microbiota.
- Other names
- allogeneic human faecal transplantFMTstool transplantfecal bacteriotherapyfecal microbiota transplantation
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