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fecal microbiota transplant (Lawson Health Research Institute)
- Development stage
- Unknown
- Lead developer
- Lawson Health Research Institute
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
An investigational fecal microbiota transplant (FMT) therapy being studied for the treatment of rheumatoid arthritis. Developed by Lawson Health Research Institute (the research institute of London Health Sciences Centre and St. Joseph's Health Care London), this therapy consists of oral capsules containing processed fecal microbiota from screened healthy donors. The modality is a live biotherapeutic product intended to modify the gut microbiome. The presumed mechanism of action involves restoring a healthy composition of gut bacteria, which may in turn modulate the immune system and reduce autoimmune activity. It is being evaluated in a randomized, double-blind, placebo-controlled proof-of-concept study known as the FeMiTRA01 trial (NCT05790356) in patients with rheumatoid arthritis.
- Other names
- fecal microbiota transplantFMT
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