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fecal microbiota transplant (Massachusetts General Hospital)
- Development stage
- Unknown
- Lead developer
- Massachusetts General Hospital
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Fecal microbiota transplant (FMT) is an investigational live biotherapeutic product being developed by Massachusetts General Hospital for the treatment of hepatic encephalopathy. Administered as oral capsules, the therapy consists of live bacterial communities derived from the fecal matter of healthy donors. [6] The primary mechanism of action is the restoration of a healthy gut microbiome, aiming to correct the dysbiosis commonly found in patients with cirrhosis and hepatic encephalopathy. [2, 6, 8] By introducing beneficial bacteria, such as those from the Ruminococcaceae and Bifidobacteriaceae families, FMT is intended to reduce the intestinal burden of harmful, neurotoxin-producing organisms, thereby improving cognitive function. [3, 4] The therapy is being evaluated in a Phase 2 clinical trial (NCT03420482). [2, 4, 5]
- Other names
- Fecal Microbiota Transplant for Hepatic Encephalopathy
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