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Fecal Microbiota Transplant (Mayo Clinic)
- Development stage
- Unknown
- Lead developer
- Mayo Clinic
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
Fecal Microbiota Transplant (FMT) is a therapeutic procedure used to restore a healthy microbial balance in the gut by transferring stool from a healthy donor into the gastrointestinal tract of a recipient. This specific intervention, developed and studied by the Mayo Clinic, focuses on treating recurrent Clostridioides difficile infection (CDI) in pediatric patients. The treatment aims to displace the pathogenic C. difficile bacteria and restore the diversity of the intestinal microbiome, which is often depleted following antibiotic use. The Mayo Clinic study specifically evaluates the comparative efficacy of fresh stool from familial donors versus frozen, banked stool from anonymous screened donors.
- Other names
- FMTFecal Microbial TransplantFresh familial donor stoolFrozen anonymous donor stool
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