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fecal microbiota transplant capsule

Development stage: Unknown
Lead developer: Shanxi Provincial People's Hospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Fecal microbiota transplant (FMT) capsules are an oral formulation containing a processed and encapsulated consortium of live microorganisms derived from the stool of healthy donors. This specific program, evaluated by Shanxi Provincial People's Hospital, is being investigated for the treatment of chronic kidney disease (CKD). The therapy aims to modulate the gut-kidney axis by restoring a healthy and diverse gut microbiome. This restoration is intended to reduce the production and accumulation of gut-derived uremic toxins (such as p-cresyl sulfate and indoxyl sulfate) and dampen systemic inflammation, which are key drivers of renal decline and cardiovascular complications in CKD patients.

Other names: fecal capsuleoral fecal microbiota transplant capsules

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