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Fecal Microbiota Transplantation (Microbiome Health Research Institute)
- Development stage
- Unknown
- Lead developer
- OpenBiome
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
This investigational fecal microbiota transplantation (FMT) therapy is being developed by the Microbiome Health Research Institute (operating as OpenBiome) for the treatment of pediatric malnutrition. The intervention, evaluated in the THRIVE (Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema) study, involves the administration of healthy donor human intestinal microbiota via a rectal catheter enema. The goal is to repair the immature gut microbiome typically found in children with severe acute malnutrition (SAM) or moderate acute malnutrition (MAM), which often fails to recover even after standard nutritional supplementation. By restoring a diverse and healthy microbial community, the therapy aims to improve nutritional outcomes and clinical recovery in children who have failed standard-of-care nutritional therapy.
- Other names
- FMTMicrobiota Transplant TherapyMTT
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