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fecal microbiota transplantation (Aarhus University)

Development stage: Preclinical
Lead developer: Aarhus University
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal

Overview

Fecal microbiota transplantation as investigated by Aarhus University is a biologic, live biotherapeutic product therapy being studied for the treatment of recurrent *Clostridioides difficile* infection (rCDI). It is a clinical research intervention consisting of processed fecal material containing live gut microbiota from healthy, screened donors. The mechanism of action involves restoring a healthy gut microbiome, which inhibits the growth of *C. difficile*. In a randomized clinical trial at Aarhus University Hospital (NCT02743234), the intervention was administered as a frozen-thawed preparation via colonoscopy or a nasojejunal tube, following pretreatment with vancomycin. The trial demonstrated a 92% clinical resolution rate for this approach, which was significantly higher than for fidaxomicin (42%) or vancomycin (19%) monotherapies. [15]

Other names: fecal microbiota transplantation-University of Aarhus-Clostridium difficile infectionFMTv

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