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fecal microbiota transplantation (Medical University of Graz)

Development stage: Unknown
Lead developer: Medizinische Universität Graz Open Science
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal

Overview

Fecal microbiota transplantation (FMT) is a biologic therapy being developed by the Medical University of Graz for the treatment of steroid-refractory acute gastrointestinal graft-versus-host disease (GI-aGvHD). The therapy involves transferring the complete fecal microbiota from healthy donors to patients to restore physiological gut microbiota. The primary mechanism is the restoration of gut microbiota diversity and composition, which is severely disrupted in GI-aGvHD. This aims to re-establish colonization resistance and the presence of beneficial commensal bacteria, which can modulate intestinal epithelial cell damage and immune responses. An ongoing Phase 3 trial sponsored by the Medical University of Graz is evaluating this therapy in patients with acute gastrointestinal GvHD after allogeneic stem cell transplantation. [8]

Other names: fecal microbiota transplantation-Medical University of Graz-graft-versus-host diseaseFMT

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